Ocular immunology and inflammation · 2007
Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kim Stephen J, Equi Robert, Belair Marie-Lyne, Fine Howard F, Dunn James P
Аннотация
PURPOSE: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART).
DESIGN: Interventional case report.
METHODS: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART.
RESULTS: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year.
CONCLUSIONS: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
DESIGN: Interventional case report.
METHODS: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART.
RESULTS: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year.
CONCLUSIONS: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
Предметные рубрики MeSH
AIDS-Related Opportunistic InfectionsAcyclovirAdultAntiretroviral Therapy, Highly ActiveAntiviral AgentsCD4 Lymphocyte CountDisease ProgressionDrug Therapy, CombinationFemaleFoscarnetGanciclovirHerpes Zoster OphthalmicusHerpesvirus 3, HumanHumansPolymerase Chain ReactionRNA, ViralRetinal Necrosis Syndrome, AcuteValacyclovirValineVision, Ocular