Radiation synthesis of multifunctional polymeric hydrogels for oral delivery of insulin.

Polyelectrolyte crosslinked hydrogel was synthesized using gamma radiation-induced copolymerization of methacrylic acid (MAA), N,N-dimethyl aminoethyl methacrylate (DMAEMA) in aqueous solution to utilize for oral delivery of insulin. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion in the glassy polymer was discussed. In addition, the swelling kinetics tests on MAA/DMAEMA (90/10) reveal that the swelling kinetics of the proposed hydrogel follows a Fickian diffusion process in media of pH 5, and an anomalous diffusion process in media of pH 1.5 and 7.2. The cross-linked three-dimensional polymers were characterized by scanning electron microscopy and FT-IR. In the matrices with increase in the content of MAA had shown increased bioadhesivity. Insulin was entrapped in these gels and the in vitro release profiles were established separately in both (SGF, pH 1.5) and (SIF, pH 7.2). The release profile of insulin showed negligible release in acidic media (SGF, pH 1.5) and sustained release in simulated intestinal fluid (SIF, pH 7.2). Drug release studies showed that the increasing content of MAA in the copolymer enhances release in SIF to design and improve insulin release behavior from these carriers.