Медицинская библиотека · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2008

[Determination of residual solvents in ranolazine by headspace gas chromatography].

Ye Ya-Lin, Yang Xue-Mei

Аннотация на английскомСтатьяПеревод в очереди

Аннотация

OBJECTIVE

To determine the contents of the residual solvents, methanol, ethanol, toluene, dichloromethane and dioxane in ranolazine raw material.

METHODS

Headspace gas chromatography was used to analyze the residual solvents quantitatively. Samples were analyzed on an HP-INNOWAX column with column temperature at 45 degrees Celsius; using water as solvent.

RESULTS

Five residual solvents were completely separated. The liner range and recoveries were satisfied. RSD of precision and accuracy was less than 8% with average recoveries between 87.1% and 105.6%.

CONCLUSION

The method could be used for the quality control of ranolazine raw material.

Для цитирования: Ye Ya-Lin, Yang Xue-Mei. [Determination of residual solvents in ranolazine by headspace gas chromatography].. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2008.

Предметные рубрики MeSH

Acetanilides Chromatography, Gas Drug Contamination Enzyme Inhibitors Ethanol Methanol Piperazines Ranolazine Reproducibility of Results Solvents Toluene

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