Powder homogenization using a hammer mill.

Hammer mill applicability in the comixing milling operation is discussed with reference to a 1:1000 microfine salicylic acid-sucrose binary system. The hammer mill would not serve as a mixing machine under most circumstances because of the low holdup capacity. Grinding of pure materials was preferable to mixture grinding since active ingredients could be lost during the milling operation. Remixing was always necessary following comminution of the mixture in the hammer mill. Grinding followed by remixing considerably enhanced mixture homogeneity. A large size range was produced by comminution, which resulted in the segregation of ordered units such that the final mixture could be described as a randomized ordered mixture.