An unprecedented compound from the dichloromethane solubles of the tropical marine sponge Agelas oroides.

Further investigation into the natural product chemistry of the tropical marine sponge Agelas oroides has yielded the new compound 2,4,6,6-tetramethyl-3(6 H)-pyridone (1), and 2,2,6,6-tetramethyl-4-piperidone (2). Both compounds are volatile. The structures of 1 and 2 were determined from the interpretation of their 1D and 2D NMR, UV, IR, and mass spectral data.