Медицинская библиотека · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials · 2006

[The anti-respiratory syncytial virus effect of active compound of Glycyrrhiza GD4 in vitro].

Wang Xiu-qin, Li Hong-yuan, Liu Xin-yan, Zhang Feng-mei, Li Xia, Piao Ying-ai, Xie Zhi-ping, Chen Zhen-hua, Li Xin

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Аннотация

OBJECTIVE

To study the effect on anti-respiratory syncytial virus of an active compound GD4 from Glycyrrhiza in vitro.

METHODS

GD4 was extracted from Glycyrrhiza by hot water extraction, dichloromethane extraction and column chromatography. The CPE inhibition assay was used to test the antiviral activity of GD4 on RSV in Hela cells.

RESULTS

GD4 was effective antiviral agent for RSV in a concentration-dependent manner and its median toxic concentration (TC50) and median effeicacious concentration (EC50) and treatment index (TI) was 0.23 mg/ml, 28.73 microg/ml and 8.0. 120 microg/ml GD4 exhibited inhibitory effect when added into cell culture for every 2h within 12h post-infection. GD4 didn't contain glycyrrhizic acid.

CONCLUSION

The active compound of Glycyrrhiza (GD4) was an evident inhibitory effect on RSV.

Для цитирования: Wang Xiu-qin, Li Hong-yuan, Liu Xin-yan, Zhang Feng-mei, Li Xia, Piao Ying-ai, Xie Zhi-ping, Chen Zhen-hua, Li Xin. [The anti-respiratory syncytial virus effect of active compound of Glycyrrhiza GD4 in vitro].. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2006.

Предметные рубрики MeSH

Antiviral Agents Dose-Response Relationship, Drug Drugs, Chinese Herbal Glycyrrhiza HeLa Cells Humans Plants, Medicinal Respiratory Syncytial Viruses Ribavirin Virus Replication

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