Медицинская библиотека · Medical science monitor : international medical journal of experimental and clinical research · 2015

Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats.

Shi Yan, Guo Li, Shi Lu, Yu Jinyang, Song Min, Li Yana

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Our aim was to study the effect of caffeic acid phenethyl ester (CAPE) on iNOS and cystathionine gamma-lyase (CSE) of hepatic fibrosis rat, and discuss the anti-hepatic fibrosis mechanism of caffeic acid phenethyl ester.

MATERIAL AND

METHODS

We observed changes of NO and H2S in serum of hepatic fibrosis rats. Enzyme-linked immunosorbent assay was used to test OD value of iNOS and CSE in serum of each. The expressions of iNOS and CSE protein in the liver were also detected by immunohistochemistry.

RESULTS

Compared with the model group, the expression of NO and iNOS was decreased obviously and the level of H2S and CSE was increased in the CAPE group.

CONCLUSIONS

CAPE has the effect of anti-hepatic fibrosis, which can be realized through adjusting the expression level of iNOS and CSE.

Для цитирования: Shi Yan, Guo Li, Shi Lu, Yu Jinyang, Song Min, Li Yana. Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats.. Medical science monitor : international medical journal of experimental and clinical research. 2015. DOI: 10.12659/msm.895272.

Предметные рубрики MeSH

Animals Caffeic Acids Cystathionine gamma-Lyase Disease Models, Animal Enzyme-Linked Immunosorbent Assay Gene Expression Profiling Gene Expression Regulation, Enzymologic Hydrogen Sulfide Immunohistochemistry Liver Liver Cirrhosis Male Nitric Oxide Synthase Type II Phenylethyl Alcohol Rats Rats, Sprague-Dawley

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