Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2012
Sustained topical delivery of insulin from fibrin gel loaded with poly(lactic-co-glycolic Acid) microspheres improves the biomechanical retention of titanium implants in type 1 diabetic rats.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Han Yong, Zeng Qing, E Lingling, Wang Dongsheng, He Huixia, Liu Hongchen
Аннотация
PURPOSE: The aim of this study was to determine whether local insulin delivery using a fibrin gel (FG) loaded with insulin/poly(lactic-co-glycolic acid) microspheres (FGIPM) improves the biomechanical retention of titanium implants in type 1 diabetic rats.
MATERIALS AND METHODS: Rats were divided randomly into 8 groups: a group of healthy rats (no treatment), a group of diabetic rats (no treatment), and 6 groups of diabetic rats treated locally using carriers containing or not containing insulin. Rats received implants in the tibia and were allowed to heal for 4 or 8 weeks. Removal torque tests (RTQ) were performed to evaluate the biomechanical retention of the implants.
RESULTS: In the diabetic control group, the mean RTQ values were significantly decreased compared with those for the healthy group. The local application of FGIPM increased the RTQ values in diabetic rats to the values found in the healthy rats at 8 weeks. The FG-treated group presented statistically significant higher mean RTQ values than the diabetic rats receiving no treatment.
CONCLUSIONS: Local insulin delivery using FGIPM ameliorated the biomechanical retention of titanium implants in type 1 diabetic rats and the FG had a beneficial effect.
MATERIALS AND METHODS: Rats were divided randomly into 8 groups: a group of healthy rats (no treatment), a group of diabetic rats (no treatment), and 6 groups of diabetic rats treated locally using carriers containing or not containing insulin. Rats received implants in the tibia and were allowed to heal for 4 or 8 weeks. Removal torque tests (RTQ) were performed to evaluate the biomechanical retention of the implants.
RESULTS: In the diabetic control group, the mean RTQ values were significantly decreased compared with those for the healthy group. The local application of FGIPM increased the RTQ values in diabetic rats to the values found in the healthy rats at 8 weeks. The FG-treated group presented statistically significant higher mean RTQ values than the diabetic rats receiving no treatment.
CONCLUSIONS: Local insulin delivery using FGIPM ameliorated the biomechanical retention of titanium implants in type 1 diabetic rats and the FG had a beneficial effect.
Предметные рубрики MeSH
Administration, TopicalAnimalsBiomechanical PhenomenaDelayed-Action PreparationsDental ImplantsDental MaterialsDental Prosthesis RetentionDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Drug CarriersDrug Delivery SystemsFibrinHypoglycemic AgentsInsulinLactic AcidMaleMicroscopy, Electron, ScanningMicrospheresPlacebosPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRandom AllocationRatsRats, WistarStreptozocinTime FactorsTitaniumTorque