Число сексуальных партнеров в течение всей жизни: показатель рискованного поведения или репродуктивной пригодности?
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Noah R. Berley, Brooke M. Huibregtse, Luke M. Evans, Michael C. Stallings
Аннотация
Оригинал публикации
Lifetime Number of Sexual Partners: A Measure of Risk-Taking Behavior or Reproductive Fitness?
Abstract The number of lifetime sexual partners is a controversial metric, potentially representing both a dimension of reproductive fitness and a component of risky behavior. This study sought to disentangle the genetic architecture of this trait to determine its relationship with risk-taking and reproductive fitness constructs. We utilized summary statistics from several Genome-Wide Association Studies (GWAS) for phenotypes related to risk-taking (e.g., general risk-taking, smoking, speeding propensity) and fitness (e.g., age at first birth, number of children ever born). Using Genomic Structural Equation Modeling (GenomicSEM), we found that number of sexual partners correlated more strongly with risk-related variables than with fitness variables. A two-factor model separating risk and fitness provided a better fit to the data than a single-factor model. In this model, number of partners loaded more strongly on the risk factor (0.84) than the fitness factor (0.16), suggesting its genetic underpinnings are more closely aligned with risk-taking behaviors. Additionally, bidirectional Mendelian randomization analyses revealed evidence of causal relationships between the number of partners and other externalizing traits like speeding and problem drinking. Our findings indicate that while the relationship is complex, the genetic architecture of lifetime number of sexual partners is more closely related to general risk-taking phenotypes than to measures of reproductive fitness.