Epilepsia · 2026
Cross-cultural adaptation and validation of the Russian versions of the Global Assessment of Disability Related to Seizures and Global Assessment of Severity of Epilepsy scales.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
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Rider Flora, Turchinets Alexander, Zinchuk Mikhail, Kustov Georgii, Tikhonova Olga, Popova Sofya, Yakovlev Alexander, Wiebe Samuel, Guekht Alla
Аннотация
OBJECTIVE: The purpose of the study was to evaluate the usefulness and reliability of the Russian versions of the Global Assessment of Disability Related to Seizures (GADS) and Global Assessment of Severity of Epilepsy (GASE), as Patient-Reported Outcomes Measures (PROMs), among patients with epilepsy (PWE) in the Russian population. Additionally, we aimed to identify predictors of seizure-related disability and epilepsy severity in our patients.
METHODS: Data from 186 adult PWE consecutively enrolled in the outpatient clinic of the Moscow Research and Clinical Center for Neuropsychiatry were used to assess the validity of the scales. Clinical and demographic data were collected. Patients completed the GADS and GASE scales and a range of other measures (Neurological Disorders Depression Inventory for Epilepsy, Epilepsy Anxiety Survey Instrument-brief version, Quality of Life in Epilepsy Inventory-31, EpiTrack, Epilepsy Stigma Scale) to assess the psychometric properties of the scales. Multiple linear regression models were developed to identify predictors of patient-reported disability from seizures and epilepsy severity.
RESULTS: Both GADS and GASE demonstrated convergent validity, known-groups validity, and construct validity. The most significant predictors of GADS score included the frequency of seizures, achieving 1-year seizure freedom, official disability status, employment status, stigma, and anxiety. The main predictor of GASE scores was self-reported disability due to seizures (GADS), followed by quality of life, frequency of seizures, stigma, and cognitive function.
SIGNIFICANCE: The study confirmed the validity and usefulness of the Russian versions of the GADS and GASE scales, which can be used in both clinical and research settings.
METHODS: Data from 186 adult PWE consecutively enrolled in the outpatient clinic of the Moscow Research and Clinical Center for Neuropsychiatry were used to assess the validity of the scales. Clinical and demographic data were collected. Patients completed the GADS and GASE scales and a range of other measures (Neurological Disorders Depression Inventory for Epilepsy, Epilepsy Anxiety Survey Instrument-brief version, Quality of Life in Epilepsy Inventory-31, EpiTrack, Epilepsy Stigma Scale) to assess the psychometric properties of the scales. Multiple linear regression models were developed to identify predictors of patient-reported disability from seizures and epilepsy severity.
RESULTS: Both GADS and GASE demonstrated convergent validity, known-groups validity, and construct validity. The most significant predictors of GADS score included the frequency of seizures, achieving 1-year seizure freedom, official disability status, employment status, stigma, and anxiety. The main predictor of GASE scores was self-reported disability due to seizures (GADS), followed by quality of life, frequency of seizures, stigma, and cognitive function.
SIGNIFICANCE: The study confirmed the validity and usefulness of the Russian versions of the GADS and GASE scales, which can be used in both clinical and research settings.