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microPublication biology · 2025

Genetic Mapping and Phenotypic Characterization of the Drosophila AIF e04281 Allele Reveals Mutant Clone Loss in Mosaic Eyes.

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Аннотация

As part of the Fly-CURE consortium, a mutant allele of Apoptosis inducing factor ( AIF ) was characterized using complementation mapping, genomic sequencing, and mosaic phenotypic analysis to investigate its role in cell growth control in Drosophila melanogaster . The AIF e04281 mutation dramatically reduced homozygous mutant clone size and caused morphological defects in genetically mosaic eyes. Sequencing confirmed a transposon insertion that truncates the AIF protein preceding conserved domains essential for mitochondrial function and apoptosis. The observed clone loss indicates a cell-autonomous requirement for AIF and supports the use of AIF e04281 as a loss-of-function background for genetic modifier screens on chromosome arm 2L.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

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