Expert opinion on biological therapy · 2008
Spray drying TB vaccines for pulmonary administration.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Fourie P B, Germishuizen W A, Wong Y-L, Edwards D A
Аннотация
BACKGROUND: New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette-Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung.
OBJECTIVES: To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery.
METHODS: Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects.
RESULTS/CONCLUSION: Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.
OBJECTIVES: To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery.
METHODS: Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects.
RESULTS/CONCLUSION: Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.