Metabolomics : Official journal of the Metabolomic Society · 2024
Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion.
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Ong Marilyn L Y, Green Christopher G, Rowland Samantha N, Rider Katie, Sutcliffe Harry, Funnell Mark P, Salzano Andrea, Heaney Liam M
Аннотация
INTRODUCTION: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
OBJECTIVES/METHODS: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
RESULTS: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
CONCLUSION: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
OBJECTIVES/METHODS: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
RESULTS: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
CONCLUSION: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.