Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology.
СтатьяСистематический обзорConsensus StatementПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Lieberman Jay A, Chu Derek K, Ahmed Tasnuva, Dribin Timothy E, Abrams Elissa M, Anagnostou Aikaterini, Blumenthal Kimberly G, Boguniewicz Mark, Chase Nicole M, Golden David B K, Hartog Nicholas L, Heimall Jennifer R, Ho Tina, Lawrence Monica G, Khan David A, Minniear Timothy Dean, Mustafa S Shahzad, Oppenheimer John J, Phillips Elizabeth J, Ramsey Allison, Rider Nicholas L, Schneider Lynda, Shaker Marcus S, Spergel Jonathan M, Stone Cosby A, Stukus David R, Wang Julie, Greenhawt Matthew J
Аннотация
BACKGROUND: Dupilumab is a monoclonal antibody that targets the interleukin (IL)-4 receptor alpha subunit, thus blocking the effects of IL-4 and IL-13, and has shown efficacy in treating various conditions including asthma, atopic dermatitis, eosinophilic esophagitis, and others. Because of its immune modulatory effects, clinical trials that studied dupilumab did not allow patients to receive live vaccines during the clinical trials because of an abundance of caution, and thus package inserts recommend that patients who are being treated with dupilumab should avoid live vaccines. Because dupilumab is now approved for use in patients from 6 months of age for the treatment of atopic dermatitis, this reported contraindication is now posing a clinical dilemma for patients and clinicians.
OBJECTIVE: To perform a systematic review of literature on the safety and efficacy of vaccinations in patients who are receiving dupilumab and to provide expert guidance on the use of vaccines in patients who are receiving dupilumab.
METHODS: A systematic review of the literature was performed, and an expert Delphi Panel was assembled.
RESULTS: The available literature on patients who received vaccinations while using dupilumab overall suggests that live vaccines are safe and that the vaccine efficacy, in general, is not affected by dupilumab. The expert Delphi panel agreed that the use of vaccines in patients receiving dupilumab was likely safe and effective.
CONCLUSION: Vaccines (including live vaccines) can be administered to patients receiving dupilumab in a shared decision-making capacity.
OBJECTIVE: To perform a systematic review of literature on the safety and efficacy of vaccinations in patients who are receiving dupilumab and to provide expert guidance on the use of vaccines in patients who are receiving dupilumab.
METHODS: A systematic review of the literature was performed, and an expert Delphi Panel was assembled.
RESULTS: The available literature on patients who received vaccinations while using dupilumab overall suggests that live vaccines are safe and that the vaccine efficacy, in general, is not affected by dupilumab. The expert Delphi panel agreed that the use of vaccines in patients receiving dupilumab was likely safe and effective.
CONCLUSION: Vaccines (including live vaccines) can be administered to patients receiving dupilumab in a shared decision-making capacity.