PLoS pathogens · 2020

Characterizing Emerging Canine H3 Influenza Viruses.

СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди

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Martinez-Sobrido Luis, Blanco-Lobo Pilar, Rodriguez Laura, Fitzgerald Theresa, Zhang Hanyuan, Nguyen Phuong, Anderson Christopher S, Holden-Wiltse Jeanne, Bandyopadhyay Sanjukta, Nogales Aitor, DeDiego Marta L, Wasik Brian R, Miller Benjamin L, Henry Carole, Wilson Patrick C, Sangster Mark Y, Treanor John J, Topham David J, Byrd-Leotis Lauren, Steinhauer David A, Cummings Richard D, Luczo Jasmina M, Tompkins Stephen M, Sakamoto Kaori, Jones Cheryl A, Steel John, Lowen Anice C, Danzy Shamika, Tao Hui, Fink Ashley L, Klein Sabra L, Wohlgemuth Nicholas, Fenstermacher Katherine J, El Najjar Farah, Pekosz Andrew, Sauer Lauren, Lewis Mitra K, Shaw-Saliba Kathryn, Rothman Richard E, Liu Zhen-Ying, Chen Kuan-Fu, Parrish Colin R, Voorhees Ian E H, Kawaoka Yoshihiro, Neumann Gabriele, Chiba Shiho, Fan Shufang, Hatta Masato, Kong Huihui, Zhong Gongxun, Wang Guojun, Uccellini Melissa B, García-Sastre Adolfo, Perez Daniel R, Ferreri Lucas M, Herfst Sander, Richard Mathilde, Fouchier Ron, Burke David, Pattinson David, Smith Derek J, Meliopoulos Victoria, Freiden Pamela, Livingston Brandi, Sharp Bridgett, Cherry Sean, Dib Juan Carlos, Yang Guohua, Russell Charles J, Barman Subrata, Webby Richard J, Krauss Scott, Danner Angela, Woodard Karlie, Peiris Malik, Perera R A P M, Chan M C W, Govorkova Elena A, Marathe Bindumadhav M, Pascua Philippe N Q, Smith Gavin, Li Yao-Tsun, Thomas Paul G, Schultz-Cherry Stacey

Аннотация

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

Предметные рубрики MeSH

Animals Communicable Diseases, Emerging Dog Diseases Dogs Ferrets Guinea Pigs Humans Influenza A Virus, H3N2 Subtype Influenza A Virus, H3N8 Subtype Influenza A virus Influenza, Human Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA United States Zoonoses

Characterizing Emerging Canine H3 Influenza Viruses.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH