Frontiers in oncology · 2026
Case Report: rapid clinical complete response to Iparomlimab and Tuvonralimab combined with radiotherapy and chemotherapy in a patient with MSS/pMMR locally advanced rectal cancer.
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Wang Jue, Yang Tao, Zhou Jingrui, Chen Weimin, Wang Guiwei, Mei Chaoyu, Chen Ziwei, Li Jibiao, Shen Tao
Аннотация
OBJECTIVE: To investigate the efficacy and safety of Iparomlimab and Tuvonralimab, a PD-1/CTLA-4 bispecific antibody, in combination with chemoradiotherapy for a patient with microsatellite stable/mismatch repair proficient (MSS/pMMR) locally advanced rectal cancer (LARC), and to analyze the mechanism of achieving short-term clinical complete response (cCR).
METHODS: This case report presents a 61-year-old male with stage cT3N2aM0 IIIB MSS/pMMR rectal cancer. The patient received neoadjuvant therapy with Iparomlimab and Tuvonralimab (300mg per dose) plus XELOX regimen chemotherapy and radiotherapy (45Gy/25F). Responses were regularly assessed via digital rectal examination, imaging, endoscopy, and pathology.
RESULTS: After treatment, clinical complete response (cCR) was initially evidenced by MRI at week 12 and subsequently confirmed by endoscopic assessment combined with pathologic biopsy at week 20. No grade 3 or higher immune-related adverse events occurred. At the last follow-up in March 2026, no recurrence was observed.
CONCLUSION: This case suggests that Iparomlimab and Tuvonralimab combined with chemoradiotherapy may induce rapid cCR in MSS/pMMR LARC, offering a promising organ-preserving strategy through immunotherapy. Further large-sample studies are warranted.
METHODS: This case report presents a 61-year-old male with stage cT3N2aM0 IIIB MSS/pMMR rectal cancer. The patient received neoadjuvant therapy with Iparomlimab and Tuvonralimab (300mg per dose) plus XELOX regimen chemotherapy and radiotherapy (45Gy/25F). Responses were regularly assessed via digital rectal examination, imaging, endoscopy, and pathology.
RESULTS: After treatment, clinical complete response (cCR) was initially evidenced by MRI at week 12 and subsequently confirmed by endoscopic assessment combined with pathologic biopsy at week 20. No grade 3 or higher immune-related adverse events occurred. At the last follow-up in March 2026, no recurrence was observed.
CONCLUSION: This case suggests that Iparomlimab and Tuvonralimab combined with chemoradiotherapy may induce rapid cCR in MSS/pMMR LARC, offering a promising organ-preserving strategy through immunotherapy. Further large-sample studies are warranted.