Immunomodulatory Function of Soluble Dietary Fiber: Toward Application for Prevention and Treatment of Food Allergies.

PURPOSE OF REVIEW: Gastrointestinal dysbiosis is implicated in the disruption of immune homeostasis and the pathogenesis of food allergies. Consequently, dietary fibers have gained attention as key molecules modulating microbial balance and immunity. This review aims to explore the immunomodulatory functions of dietary fibers commonly found in the human diet, including pectin, inulin, β-glucan, and mannan.

RECENT FINDINGS: Dietary fibers affect the immune system through two primary pathways: direct interaction with pattern recognition receptors and indirect action via microbial metabolism. In the indirect pathway, the gut microbiome utilizes these fibers as an energy source to produce a diverse range of metabolites. Notably, these fiber-derived processes exhibit a dual nature in food allergies, showing potential to either suppress or, in some cases, promote allergic inflammation. Understanding the unique physicochemical and physiological characteristics of individual types of fibers is important for the rational development of dietary-based prevention and treatment strategies in food allergies.