Irish journal of medical science · 2026
Atopic dermatitis management: integrating disease mechanisms with precision medicine and nanotechnology-based targeted therapies.
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Nazeer Iqra, Mubeen Hira, Azam Sabiya
Аннотация
BACKGROUND: Atopic Dermatitis is a chronic, multi-factorial skin inflammation disorder characterized by immune dysregulation, skin barrier dysfunction, microbial imbalance and environmental triggers. Despite advances in conventional and biological therapies, challenges persist in early diagnosis, disease classification, treatment personalization and long-term management. Emerging technologies integrating precision medicine and nanotechnology offer promising solutions to address these limitations.
OBJECTIVES: This review aims to highlight the integration of precision medicine and advanced nanocarrier systems into the prediction, diagnosis and targeted treatment of atopic dermatitis.
METHOD: This review identifies key gaps in clinical, translational and personalized dermatological research. The review gives deep insights into current evidence on clinical practices and multi-omics approaches for AD phenotyping, biomarker discovery, disease severity assessment, and prediction of advanced therapeutic approaches.
RESULTS: The integration of multi-omics data approaches and translational research methods significantly enhance the classification of disease severity, and provides wonders in discovery of potential biomarkers for measuring response and suggesting treatment.
CONCLUSION: Integrating these multidisciplinary approaches has the potential to optimize patient stratification, improve treatment outcomes, and advance sustainable dermatological care.
OBJECTIVES: This review aims to highlight the integration of precision medicine and advanced nanocarrier systems into the prediction, diagnosis and targeted treatment of atopic dermatitis.
METHOD: This review identifies key gaps in clinical, translational and personalized dermatological research. The review gives deep insights into current evidence on clinical practices and multi-omics approaches for AD phenotyping, biomarker discovery, disease severity assessment, and prediction of advanced therapeutic approaches.
RESULTS: The integration of multi-omics data approaches and translational research methods significantly enhance the classification of disease severity, and provides wonders in discovery of potential biomarkers for measuring response and suggesting treatment.
CONCLUSION: Integrating these multidisciplinary approaches has the potential to optimize patient stratification, improve treatment outcomes, and advance sustainable dermatological care.