Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2026
Investigation of overnight growth hormone secretion patterns in the clinical diagnosis of growth hormone neurosecretory dysfunction.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Atas Nurgul, Kopan Mehmet Ali, Melik Fatoş Çirkin, Keskin Mehmet, Karaoğlan Murat
Аннотация
OBJECTIVE: Growth hormone neurosecretory dysfunction (NSD) is a clinical condition characterized by impaired spontaneous, particularly nocturnal, growth hormone (GH) secretion despite a normal response to pharmacological GH stimulation tests. This study aimed to compare overnight GH secretion patterns between children with and without NSD despite normal GH stimulation test results and to investigate the potential contribution of GH secretion dynamics to the identification of NSD.
MATERIALS AND METHODS: In this retrospective observational study, 91 children evaluated for short stature between January 2025 and May 2026, who had a peak GH level > 8 ng/mL on GH stimulation testing and underwent overnight serial GH sampling for the evaluation of NSD, were included. Patients with a mean overnight GH concentration < 3 ng/mL were classified as the NSD group (n = 41), whereas those with a mean GH concentration ≥ 3 ng/mL were classified as the non-NSD group (n = 50). Overnight GH secretion parameters were compared between the groups, and exploratory hierarchical cluster analysis was performed to characterize GH secretion patterns.
RESULTS: Of the 91 patients, 41 (45.1%) were classified as having NSD. Demographic and clinical characteristics, as well as peak GH levels obtained during GH stimulation testing, were comparable between the two groups (all p > 0.05). The NSD group had significantly lower mean, maximum, and minimum overnight GH concentrations, as well as lower GH standard deviation, compared with the non-NSD group (all p < 0.001), whereas the coefficient of variation was significantly higher (p = 0.002). No significant difference was observed in the number of GH peaks between the groups (p = 0.20). Exploratory hierarchical cluster analysis identified five distinct GH secretion clusters, and cluster distribution was significantly associated with NSD status (χ2 = 49.15, p < 0.001).
CONCLUSION: A substantial proportion of children with short stature and normal GH stimulation test results exhibited overnight GH secretion patterns consistent with NSD. Multidimensional analysis of overnight GH secretion may provide additional insights into physiological GH secretion patterns and may serve as a complementary approach for the evaluation of selected children with suspected NSD.
MATERIALS AND METHODS: In this retrospective observational study, 91 children evaluated for short stature between January 2025 and May 2026, who had a peak GH level > 8 ng/mL on GH stimulation testing and underwent overnight serial GH sampling for the evaluation of NSD, were included. Patients with a mean overnight GH concentration < 3 ng/mL were classified as the NSD group (n = 41), whereas those with a mean GH concentration ≥ 3 ng/mL were classified as the non-NSD group (n = 50). Overnight GH secretion parameters were compared between the groups, and exploratory hierarchical cluster analysis was performed to characterize GH secretion patterns.
RESULTS: Of the 91 patients, 41 (45.1%) were classified as having NSD. Demographic and clinical characteristics, as well as peak GH levels obtained during GH stimulation testing, were comparable between the two groups (all p > 0.05). The NSD group had significantly lower mean, maximum, and minimum overnight GH concentrations, as well as lower GH standard deviation, compared with the non-NSD group (all p < 0.001), whereas the coefficient of variation was significantly higher (p = 0.002). No significant difference was observed in the number of GH peaks between the groups (p = 0.20). Exploratory hierarchical cluster analysis identified five distinct GH secretion clusters, and cluster distribution was significantly associated with NSD status (χ2 = 49.15, p < 0.001).
CONCLUSION: A substantial proportion of children with short stature and normal GH stimulation test results exhibited overnight GH secretion patterns consistent with NSD. Multidimensional analysis of overnight GH secretion may provide additional insights into physiological GH secretion patterns and may serve as a complementary approach for the evaluation of selected children with suspected NSD.