Resilience of circuits to environmental challenge.

Animals of all kinds evolved to deal with anticipated and unanticipated changes in a variety of features in their environments. Consequently, all environmental perturbations, adaptations, and acclimation involve a myriad of factors that, together, contribute to environmental resilience. New work highlights the importance of neuromodulation in the control of environmental resilience, and illustrates that different components of the nervous system may be differentially resilient to environmental perturbations. Climate change is today pushing animals to deal with previously unanticipated environmental challenges, and therefore understanding the complex biology of adaptation and acclimation to various environmental conditions takes on new urgency.