Aging · 2022
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Schmauck-Medina Tomas, Molière Adrian, Lautrup Sofie, Zhang Jianying, Chlopicki Stefan, Madsen Helena Borland, Cao Shuqin, Soendenbroe Casper, Mansell Els, Vestergaard Mark Bitsch, Li Zhiquan, Shiloh Yosef, Opresko Patricia L, Egly Jean-Marc, Kirkwood Thomas, Verdin Eric, Bohr Vilhelm A, Cox Lynne S, Stevnsner Tinna, Rasmussen Lene Juel, Fang Evandro F
Аннотация
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the 'old' and 'new' hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.