Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
Symptom burden and quality of life in patients with pancreatic and peri-pancreatic cancer at admission to specialized palliative care: a nationwide register-based study in Denmark.
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Chelliah Thukirtha, Chen Inna Markovna, Fristrup Claus Wilki, Groenvold Mogens, Adsersen Mathilde
Аннотация
BACKGROUND: Most patients with pancreatic cancer have advanced disease at the time of diagnosis and a poor prognosis. Therefore, it is important to investigate the symptom burden for these patients, e.g., at the start of specialized palliative care (SPC).
AIM: To investigate symptoms, problems, and quality of life in patients with pancreatic cancer at the start of SPC and to explore the associations with demographic factors.
METHOD: The data sources were the national Danish Palliative Care Database and Danish Pancreatic Cancer Database. Patients with pancreatic and peri-pancreatic cancer, who were diagnosed and died between 2011 and 2018 and admitted to SPC were included. Data about symptoms, problems, and quality of life were collected by EORTC QLQ-C15-PAL (10 scales ranging 0-100). Using ordinal logistic regression analyses, the associations between demographic factors and the symptoms and functions scores and QOL (outcomes) were investigated.
RESULTS: From 2011-18, 3,497 patients with pancreatic cancer were admitted to SPC and 58% (N = 2028) of these completed the QLQ-C15-PAL. Patients with pancreatic cancer had a high symptom burden regarding fatigue (mean: 76), loss of appetite (mean: 68), and pain (mean: 56), whereas among function scales, low physical function (mean: 35) and low quality of life (mean: 39) were found. Younger patients and patients who had not received any anticancer treatment had a higher symptom burden.
CONCLUSION: In this nationally representative study, patients with pancreatic cancer had a high symptom burden and low quality of life at admission to SPC, underlining the need for symptom assessment and palliative care, also before referral to SPC.
AIM: To investigate symptoms, problems, and quality of life in patients with pancreatic cancer at the start of SPC and to explore the associations with demographic factors.
METHOD: The data sources were the national Danish Palliative Care Database and Danish Pancreatic Cancer Database. Patients with pancreatic and peri-pancreatic cancer, who were diagnosed and died between 2011 and 2018 and admitted to SPC were included. Data about symptoms, problems, and quality of life were collected by EORTC QLQ-C15-PAL (10 scales ranging 0-100). Using ordinal logistic regression analyses, the associations between demographic factors and the symptoms and functions scores and QOL (outcomes) were investigated.
RESULTS: From 2011-18, 3,497 patients with pancreatic cancer were admitted to SPC and 58% (N = 2028) of these completed the QLQ-C15-PAL. Patients with pancreatic cancer had a high symptom burden regarding fatigue (mean: 76), loss of appetite (mean: 68), and pain (mean: 56), whereas among function scales, low physical function (mean: 35) and low quality of life (mean: 39) were found. Younger patients and patients who had not received any anticancer treatment had a higher symptom burden.
CONCLUSION: In this nationally representative study, patients with pancreatic cancer had a high symptom burden and low quality of life at admission to SPC, underlining the need for symptom assessment and palliative care, also before referral to SPC.