Current opinion in allergy and clinical immunology · 2019
Treatable traits in chronic rhinosinusitis with nasal polyps.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Heffler Enrico, Malvezzi Luca, Pirola Francesca, Zięba Natalia, Paoletti Giovanni, Mercante Giuseppe, Spriano Giuseppe, Canonica Giorgio Walter
Аннотация
PURPOSE OF REVIEW: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory sinonasal disease that deserves a multidisciplinary precision medicine approach. In a precision medicine model, a more pragmatic approach taking in consideration disease features that are potentially treatable should be considered.
RECENT FINDINGS: Several treatable traits in CRSwNP can be identified: from disease-related ones, to extra-ENT features, to behavioral and environmental factors. This review article summarizes primarily the recent findings of CRSwNP-related treatable traits and how they can be modified by given treatments.
SUMMARY: The advent of biological agents acting directly to the endotype underlying CRSwNP pushes the scientific community to integrate clinical, surgical and immunological evaluations for each single patient; this naturally leads to the identification of specific treatable traits that can serve as possible outcomes for any single biological.
RECENT FINDINGS: Several treatable traits in CRSwNP can be identified: from disease-related ones, to extra-ENT features, to behavioral and environmental factors. This review article summarizes primarily the recent findings of CRSwNP-related treatable traits and how they can be modified by given treatments.
SUMMARY: The advent of biological agents acting directly to the endotype underlying CRSwNP pushes the scientific community to integrate clinical, surgical and immunological evaluations for each single patient; this naturally leads to the identification of specific treatable traits that can serve as possible outcomes for any single biological.