Cortical rhythm of No-go processing in humans: an MEG study.

OBJECTIVE

We investigated the characteristics of cortical rhythmic activity in No-go processing during somatosensory Go/No-go paradigms, by using magnetoencephalography (MEG).

METHODS

Twelve normal subjects performed a warning stimulus (S1) - imperative stimulus (S2) task with Go/No-go paradigms. The recordings were conducted in three conditions. In Condition 1, the Go stimulus was delivered to the second digit, and the No-go stimulus to the fifth digit. The participants responded by pushing a button with their right thumb for the Go stimulus. In Condition 2, the Go and No-go stimuli were reversed. Condition 3 was the resting control.

RESULTS

A rebound in amplitude was recorded in the No-go trials for theta, alpha, and beta activity, peaking at 600-900 ms. A suppression of amplitude was recorded in Go and No-go trials for alpha activity, peaking at 300-600 ms, and in Go and No-go trials for beta activity, peaking at 200-300 ms.

CONCLUSION

The cortical rhythmic activity clearly has several dissociated components relating to different motor functions, including response inhibition, execution, and decision-making.

SIGNIFICANCE: The present study revealed the characteristics of cortical rhythmic activity in No-go processing.