Emerging infectious diseases · 2026
Multisectoral Emergence of Multidrug-Resistant Campylobacter coli Sequence Type 10042 Lineage, Europe, 2018-2025.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Azevedo Mónica, Nunes Alexandra, Lemos Maria-Leonor, Costa Paulo Martins, Amaro Ana, Clemente Lurdes, Leão Célia, Ramos Sónia, Santos Isabel, Joensen Katrine Grimstrup, Ragimbeau Catherine, de Baets Lena, Mossong Joël, Banerji Sangeeta, Flieger Antje, Espadinha Diana, Byrne William, van den Berg Oda, Kampfraath Andries Augustus, Jehanne Quentin, Lehours Philippe, Gomes João Paulo, Oleastro Mónica
Аннотация
Campylobacter spp. remain the leading bacterial cause of foodborne gastroenteritis in Western countries. We report sustained, previously unrecognized circulation of a multidrug-resistant Campylobacter coli sequence type 10042 lineage across Europe during 2018-2025. Whole-genome sequencing of 217 isolates from 9 countries spanning human, animal, food, and environmental sources identified cross-border clusters, including a large lineage linking primarily Portugal and Luxembourg, as well as Germany, Ireland, Spain, and the United Kingdom. Genomic data indicates ongoing clonal expansion with increasing diversification over time. Isolates exhibited a conserved multidrug-resistant phenotype, including resistance to fluoroquinolones, tetracyclines, and β-lactams; reduced susceptibility to carbapenems was observed. Resistance was associated with GyrA Thr86Ile, tet(O/32/O)/tet(O) genes, and blaOXA-61 promoter variants; variation in porA was linked to variable amoxicillin/clavulanic acid and ertapenem susceptibility. Those findings demonstrate that C. coli infections can involve sustained international transmission rather than sporadic cases and highlight the need for coordinated, cross-sector genomic surveillance to detect emerging antimicrobial-resistant lineages.