Current developments in nutrition · 2026
Rationale and Design of Traditional and Adaptive Calorie Restriction and Time-Restricted Eating Interventions Used in the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial.
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Kennedy Samantha F, Cabre Hannah E, Diktas Hanim E, Falkenhain Kaja, Spring Katherine E, Peterson Courtney M, Dutton Gareth R, Drews Kimberly L, Broyles Stephanie T, Dubin Robert, Rogers Laura Q, Champagne Catherine M, Villareal Dennis T, Hsia Daniel S, Jacobs Peter G, Rejeski Jack, Fanning Jason, Redman Leanne M, Martin Corby K
Аннотация
BACKGROUND: Research shows that dietary interventions improve biomarkers of health span and aging.
OBJECTIVE: This paper describes the implementation and data collection methods for 4 dietary interventions and a control condition comprising the 5 arms of the Dietary Approaches to Longevity and Health (DiAL Health) Pilot study.
METHODS: DiAL Health is a 24-wk, randomized controlled pilot trial comparing the feasibility and preliminary efficacy of traditional and adaptive approaches to calorie restriction (CR) and time-restricted eating (TRE) on biomarkers of biological aging and health span in young, healthy adults [age: 25-49 y, body mass index (BMI): 22.0-29.9 kg/m2]. To our knowledge, this is one of the first studies to examine the effects of both CR and TRE against a usual diet and will generate preliminary data to inform a larger, longer-term comparative trial. The 2 CR arms of DiAL Health target 25% CR, whereas the 2 TRE arms promote ad libitum food intake within an 8-h daily window. Traditional CR and TRE arms will receive established interventions. The corresponding Adaptive arms will receive Just-in-Time Adaptive Interventions that leverage mobile health technologies to adjust behavior and facilitate adherence with real-time or near-real-time feedback and support. Using a validated mathematical model, weight loss nomograms with measurements from internet-connected smart scales will be used to monitor dietary adherence in the Adaptive CR arm. Feedograms with eating events populated by continuous glucose monitoring (CGM), the Remote Food Photography Method/SmartIntake app, and manual entry by counselors and participants will be used to monitor meal timing adherence in the Adaptive TRE arm. Integration of CGM will support passive, automated detection of meal timing and eating behavior, potentially reducing reliance on self-reported measures.
CONCLUSIONS: Findings from the DiAL Health Pilot study will inform the design and implementation of a future 5-y clinical trial evaluating personalized dietary strategies to promote longevity and improve health span.This trial was registered at clinicaltrials.gov as NCT05549362.
OBJECTIVE: This paper describes the implementation and data collection methods for 4 dietary interventions and a control condition comprising the 5 arms of the Dietary Approaches to Longevity and Health (DiAL Health) Pilot study.
METHODS: DiAL Health is a 24-wk, randomized controlled pilot trial comparing the feasibility and preliminary efficacy of traditional and adaptive approaches to calorie restriction (CR) and time-restricted eating (TRE) on biomarkers of biological aging and health span in young, healthy adults [age: 25-49 y, body mass index (BMI): 22.0-29.9 kg/m2]. To our knowledge, this is one of the first studies to examine the effects of both CR and TRE against a usual diet and will generate preliminary data to inform a larger, longer-term comparative trial. The 2 CR arms of DiAL Health target 25% CR, whereas the 2 TRE arms promote ad libitum food intake within an 8-h daily window. Traditional CR and TRE arms will receive established interventions. The corresponding Adaptive arms will receive Just-in-Time Adaptive Interventions that leverage mobile health technologies to adjust behavior and facilitate adherence with real-time or near-real-time feedback and support. Using a validated mathematical model, weight loss nomograms with measurements from internet-connected smart scales will be used to monitor dietary adherence in the Adaptive CR arm. Feedograms with eating events populated by continuous glucose monitoring (CGM), the Remote Food Photography Method/SmartIntake app, and manual entry by counselors and participants will be used to monitor meal timing adherence in the Adaptive TRE arm. Integration of CGM will support passive, automated detection of meal timing and eating behavior, potentially reducing reliance on self-reported measures.
CONCLUSIONS: Findings from the DiAL Health Pilot study will inform the design and implementation of a future 5-y clinical trial evaluating personalized dietary strategies to promote longevity and improve health span.This trial was registered at clinicaltrials.gov as NCT05549362.