Journal of pharmaceutical and biomedical analysis · 2026
Isolation and identification of two novel oxyphenisatin analogues found as adulterants in health food products.
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Sun Jian, Yu Hong, Kee Chee Leong, Zhang Jingxian, Ran Yingying, Huang Fan, Zhou Heng, Mao Xiuhong, Ge Xiaowei, Hu Qing
Аннотация
During non-targeted screening of a preserved fruit and a jelly health food product, two unidentified compounds were detected and subsequently isolated through prep-HPLC. Comprehensive structural elucidation under optimized conditions employing ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC/Q-TOF MS), high-performance liquid chromatography-diode array detection (HPLC-DAD), Fourier transform infrared (FT-IR), and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy confirmed the compounds as oxyphenisatin dioctanoate and 5-chloro oxyphenisatin, respectively. These findings demonstrate a persistent pattern of structural modification with increasingly esterified or halogenated derivatives of the laxative oxyphenisatin since 2023, which warrants full attention from regulatory authorities.