Processing Speed and Verbal Learning Ability as Predictors of Assessor-Rated and Ecological Momentary Assessment Self-Reported Functioning: Findings from AMP SCZ.
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Pratt Danielle N, Lewandowski Kathryn E, Hacker Hannah, Kambeitz-Ilankovic Lana, Yassin Walid, Shah Jai, Allott Kelly, Stone William S, Addington Jean, Yung Alison R, Williams Trevor F, Cowan Henry R, He Siyan, Schiffman Jason, Carrión Ricardo E, Torous John, Fusar-Poli Paolo, Lepage Martin, Kim Sung-Wan, Verma Swapna, Nordentoft Merete, Glenthøj Louise B, Smesny Stefan, Conus Philippe, Broome Matthew R, Hui Christy L M, Sabb Fred W, Perkins Diana O, Powers Albert R, Calkins Monica E, Wolf Daniel H, Corcoran Cheryl M, Horton Leslie E, Ellman Lauren M, Strauss Gregory P, Mamah Daniel, Pearlson Godfrey D, Choi Jimmy, Kim Minah, Kambeitz Joseph, Gaspar Pablo A, Mathalon Daniel H, Cadenhead Kristin S, Perez Jesus, Arango Celso, Koutsouleris Nikolaos, Silverstein Steven, Breitborde Nicholas J K, Bouix Sylvain, Baker Justin T, Kapur Tina, Pasternak Ofer, Kahn Rene S, Cecchi Guillermo, Coleman Michael J, Kane John M, McGorry Patrick D, Bearden Carrie E, Nelson Barnaby, Shenton Martha E, Woods Scott W, Mittal Vijay A
Аннотация
STUDY DESIGN: Individuals at CHR-P (n = 1282) and community controls (n = 425) who participated in Accelerating Medicines Partnership-Schizophrenia were examined. Processing speed and verbal learning abilities were ascertained using the Penn Computerized Neurocognitive Battery. Assessor-rated functioning was measured using the Global Functioning Scales. Self-reported functioning was collected using Ecological Momentary Assessment. Analyses were linear models and mixed-effects models.
STUDY RESULTS: Both processing speed and verbal learning were associated with assessor-rated functioning at baseline and through 2 months (Ps < 0.001). Processing speed abilities predicted changes in self-reported ability to function (P = .036), motivation (P = .040), and concentration (P = .020) over time. Verbal learning abilities predicted changes in self-reported loneliness (P = .044) over time. Processing speed and verbal learning were associated with assessor-rated and self-reported functioning over and above estimated intelligence quotient and positive symptoms.
CONCLUSIONS: Processing speed and verbal learning are important predictors of short-term longitudinal functioning, and may be important targets for early recognition and mitigation of psychosis risk.