International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
A family and healthcare-associated cluster of severe fever with thrombocytopenia syndrome in Shanghai, China: an epidemiological investigation in a nonendemic area.
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Zhu Yiyi, Wu Wencheng, Teng Zheng, Zheng Yaxu, Wang Yuanping, Wang Wei, Chen Jian, Pan Hao
Аннотация
OBJECTIVE: To describe the epidemiological and clinical characteristics of a cluster of severe fever with thrombocytopenia syndrome (SFTS) cases in Shanghai and assess the potential risk of healthcare-associated transmission.
METHODS: Epidemiological and clinical data were collected from seven patients, including the index case, four family members, and two healthcare workers. Serum samples from five patients were tested for SFTS virus (SFTSV) RNA and SFTSV-specific IgM antibodies.
RESULTS: The index case developed symptoms on June 12, 2018, and died on June 23. Between June 30 and July 6, three family members and one healthcare worker developed fever, thrombocytopenia, and leukopenia; SFTSV RNA was detected in their blood samples. One family member died of multiple organ failure 11 days after symptom onset. Another family member and one doctor developed febrile symptoms and were positive for SFTSV IgM antibodies. Overall, seven cases were identified, including two deaths and two infections among healthcare workers.
CONCLUSIONS: This cluster suggests possible family and healthcare-associated transmission of SFTSV in Shanghai, a nonendemic area of China. Improved clinical awareness and infection prevention are needed when managing unexplained febrile hemorrhagic illnesses.
METHODS: Epidemiological and clinical data were collected from seven patients, including the index case, four family members, and two healthcare workers. Serum samples from five patients were tested for SFTS virus (SFTSV) RNA and SFTSV-specific IgM antibodies.
RESULTS: The index case developed symptoms on June 12, 2018, and died on June 23. Between June 30 and July 6, three family members and one healthcare worker developed fever, thrombocytopenia, and leukopenia; SFTSV RNA was detected in their blood samples. One family member died of multiple organ failure 11 days after symptom onset. Another family member and one doctor developed febrile symptoms and were positive for SFTSV IgM antibodies. Overall, seven cases were identified, including two deaths and two infections among healthcare workers.
CONCLUSIONS: This cluster suggests possible family and healthcare-associated transmission of SFTSV in Shanghai, a nonendemic area of China. Improved clinical awareness and infection prevention are needed when managing unexplained febrile hemorrhagic illnesses.