American journal of surgery · 2026
Fused deposition modeling significantly reduces bioburden.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Riggenbach Zachary, Williams Brooklyn, Lutgens Jonathan, Kelly Abigail, Teng Jennifer, Alvarez Carolina, Kim Ha Eun, Gillette Laurel, Edinger Allison, Biesiada Emma, Williams James, Glaser Jacob
Аннотация
BACKGROUND: Additive manufacturing (AM), particularly fused deposition modeling (FDM), holds promise for producing surgical instruments in austere settings. However, standard sterilization methods often degrade thermoplastics used in FDM. This study evaluates whether the high temperatures inherent to FDM can reduce bioburden on post-print materials.
METHODS: Polycarbonate filament was inoculated with E. coli and S. aureus and then 3D printed at 260°C or 300°C. Printed samples and preprint controls were cultured under aerobic, anaerobic, and fungal conditions. Sterility was assessed over a 14-day incubation period.
RESULTS: Out of 30 printed samples, 5 (16.6%) showed microbial contamination, compared to 30/30 (100%) positive controls (p≪< 0.01). No significant difference was found between print temperatures or culture conditions.
DISCUSSION AND CONCLUSION: FDM significantly reduced microbial contamination under non-sterile operating conditions. This suggests further investigations should focus on a potential FDM single-stage, point-of-care sterilization method. Further work is needed to define critical parameters and validate efficacy against more resilient pathogens.
METHODS: Polycarbonate filament was inoculated with E. coli and S. aureus and then 3D printed at 260°C or 300°C. Printed samples and preprint controls were cultured under aerobic, anaerobic, and fungal conditions. Sterility was assessed over a 14-day incubation period.
RESULTS: Out of 30 printed samples, 5 (16.6%) showed microbial contamination, compared to 30/30 (100%) positive controls (p≪< 0.01). No significant difference was found between print temperatures or culture conditions.
DISCUSSION AND CONCLUSION: FDM significantly reduced microbial contamination under non-sterile operating conditions. This suggests further investigations should focus on a potential FDM single-stage, point-of-care sterilization method. Further work is needed to define critical parameters and validate efficacy against more resilient pathogens.