Neurophysiological Correlates of Neuroanatomical Dimensions in Major Depressive Disorder: Electroencephalographic Markers of Brain Function and Treatment Outcome.
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Xiao Wenyi, Woodham Rachel D, Antoniades Mathilde, Srinivasan Dhivya, Fan Yong, Erus Guray, Garcia Jose A, Arnott Stephen R, Chen Taolin, Choi Ki Sueng, Chin Fatt Cherise R, Frey Benicio N, Farzan Faranak, Frøkjær Vibe G, Ganz Melanie, Godlewska Beata R, Hassel Stefanie, Ho Keith, McIntosh Andrew M, Qin Kun, Rotzinger Susan, Sacchet Matthew D, Savitz Jonathan, Shou Haochang, Singh Ashish, Stolicyn Aleks, Strigo Irina, Strother Stephen C, Tosun Duygu, Wei Dongtao, Zahn Roland, Anderson Ian M, Craighead W Edward, Deakin J F William, Dunlop Boadie W, Elliott Rebecca, Gong Qiyong, Gotlib Ian H, Harmer Catherine J, Kennedy Sidney H, Knudsen Gitte M, Mayberg Helen S, Paulus Martin P, Qiu Jiang, Trivedi Madhukar H, Whalley Heather C, Yan Chao Gan, Young Allan H, Davatzikos Christos, Fu Cynthia H Y
Аннотация
METHODS: Baseline resting-state, eyes-closed electroencephalography (EEG) was acquired from 237 medication-free participants with MDD who were in a current depressive episode (155 women; mean age [SD] = 37.47 [13.36] years) from CAN-BIND (Canadian Biomarker Integration Network in Depression) (SSRI) and EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care) (SSRI or PLA). EEG features included spectral power, frontal alpha asymmetry (FAA), multiscale sample entropy, and intersite phase clustering. Effects of profile (D1 and D2) and clinical outcome (responder, nonresponder; defined as ≥50% symptom improvement) were examined with age, sex, and site as covariates.
RESULTS: No significant electrophysiological differences were observed after covariate adjustment. However, among participants who subsequently responded to treatment, D1 showed greater baseline alpha power in frontal and central regions and lower relative delta posteriorly compared with D2. In PLA-treated responders, D2 showed spectral slowing, elevated low-frequency power, reduced gamma, and coarse-scale entropy compared with D1. Baseline FAA was lower in responders than nonresponders, independent of the neuroanatomical profile.
CONCLUSIONS: EEG differences between MRI-defined neuroanatomical profiles emerged in relation to clinical outcome. D1 was associated with electrophysiological patterns consistent with flexible, globally regulated cortical dynamics in SSRI responders, whereas D2 showed a distinct pattern in PLA responders, indicating partially separable neural mechanisms underlying pharmacological and PLA treatment effects.