The adhesion G protein-coupled receptor F5 (ADGRF5) as an architect of immune response in cancers.

The adhesion G protein-coupled receptor F5 (ADGRF5) has emerged as a critical regulator of cellular homeostasis and disease pathogenesis. Recent investigations have revealed its dual role in driving intrinsic cancer cell aggressiveness, while orchestrating the tumor microenvironment, highlighting its untapped potential in immunotherapeutic strategies. This review provides insights into the impact of ADGRF5 expression and signaling on cancer and immune cells, underlining the essential role of ADGRF5 in cancer-related immunity. Furthermore, based on recent experimental data, the translational aspects of ADGRF5 properties are elaborated, providing a future perspective within the therapeutic area of immunooncology.