[Research progress on antioxidant mechanisms of plant-derived extracellular vesicle-like particles and their application in disease therapy].

Plant-derived extracellular vesicle-like particles(PEVLPs) are nanoscale extracellular vesicles actively secreted by plant cells, containing bioactive components such as proteins, lipids, nucleic acids, and plant-specific metabolites. Recent studies have revealed that PEVLPs possess significant antioxidant activity. They can effectively alleviate oxidative stress(OS) through multiple mechanisms, including directly scavenging reactive oxygen species(ROS), activating endogenous antioxidant pathways such as the nuclear factor E2-related factor 2(Nrf2)/antioxidant response element(ARE) signaling, and modulating the activity of antioxidant enzymes like superoxide dismutase(SOD) and catalase(CAT). This review systematically summarizes the methods for the isolation, purification, and characterization of PEVLPs, elaborates on their antioxidant mechanisms, and specifically explores their therapeutic potential in OS-related diseases, such as intestinal inflammation, metabolic disorders, and skin injury. The aim is to provide insights and references for further research and clinical application of PEVLPs in the field of traditional Chinese medicine.