AI-Driven Digital Twin Architecture for Multimodal Prediction and Adaptive Intervention in Cognitive Aging.

Age-related cognitive dysfunction, including mild cognitive impairment and dementia, underscores the need for scalable and personalized predictive models. We present a conceptual artificial intelligence-driven digital twin framework to support early detection, real-time monitoring, and adaptive intervention. The system is structured around 4 core processes: perception, analytics, decision-making, and adaptive feedback, and is organized across 5 functional layers: data acquisition, integration, modeling, reasoning, and application. Multimodal behavioral, physiological, and clinical data are harmonized using Fast Healthcare Interoperability Resources and Observational Medical Outcomes Partnership standards. Predictive modeling uses convolutional and recurrent neural networks, gradient boosting, and reinforcement learning. The framework is designed for cloud-based deployment on platforms that support HIPAA-aligned implementation, including Amazon Web Services and Microsoft Azure, with 7 application modules spanning signal-based and pose-based assessment, personalized mind-body training, cognitive rehabilitation, and disease trajectory simulation. This architecture offers a foundation for precision cognitive care in aging populations.