Spatiotemporal bursting in simulated cultures of cortical neurons.

Cultures of neurons grown on multi-electrode arrays have become a common experimental preparation for investigating developing neural networks. Experiment and simulation have shown that these developing networks eventually exhibit bursting behavior in which the entire culture participates for short periods of time, with inter-burst intervals in which the network is comparatively quiescent. This paper extends previous simulation results by examining the spatiotemporal patterns of such bursting. We show that these bursts originate at a small number of network locations and propagate as waves of activity. We demonstrate that this type of activity does not require fine tuning of neuron or network parameters. We also examine how this activity changes during development and the dependence of such activity and its triggering on both local and global network properties.