Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy.
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Ferro Matteo, Babă Dragoş-Florin, de Cobelli Ottavio, Musi Gennaro, Lucarelli Giuseppe, Terracciano Daniela, Porreca Angelo, Busetto Gian Maria, Del Giudice Francesco, Soria Francesco, Gontero Paolo, Cantiello Francesco, Damiano Rocco, Rocco Papalia, Scarpa Roberto Mario, Abu Farhan Abdal Rahman, Autorino Riccardo, Brescia Antonio, Marchioni Michele, Mari Andrea, Minervini Andrea, Longo Nicola, Chiancone Francesco, Perdona' Sisto, Barone Biagio, Placido Pietro De, Catellani Michele, Bottero Danilo, Ditonno Pasquale, Battaglia Michele, Zamboni Stefania, Antonelli Alessandro, Greco Francesco, Russo Giorgio Ivan, Smelzo Salvatore, Hurle Rodolfo, Crisan Nicolae, Manfredi Matteo, Porpiglia Francesco, Crocetto Felice, Buonerba Carlo, Danilesco Alina, Vartolomei Mihai Dorin
Аннотация
PATIENTS & METHODS: 213 patients were included.
INCLUSION CRITERIA: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC.
RESULTS: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3-50.5) and 65.37% (95% CI: 52.4-75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9-60.7) and 74.5% (95% CI: 62.6-83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points.
CONCLUSION: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC.