MedElevator
Войти в исследования BMC infectious diseases · 2026
Seroprevalence of Rift Valley fever virus and factors associated with exposure in south-central Uganda.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Nalwadda Josephine, Ssempijja Victor, Reynolds Steven J, Katushabe Gerald, Omooja Jonah, Mihalakakos Evan A, Rao Deepashri, Rosenke Kyle, Grabowski Mary K, Galiwango Ronald M, Ssekubugu Robert, Meya David, Byarugaba Denis K, Feldmann Heinz, Hawman David W
Аннотация
BACKGROUND: Rift Valley fever (RVF) poses a recurring public health and economic challenge in Uganda's cattle corridor. It is a mosquito-borne zoonotic disease caused by the Rift Valley fever virus (RVFV), with high livestock density, favorable rainfall patterns, and close human-animal interaction facilitating viral transmission and disease outbreaks. Although RVF outbreaks have occurred, data on human exposure in south-central Uganda remain limited.
METHODS: This cross-sectional study assessed the seroprevalence and associated factors of RVFV exposure among selected communities in the greater Masaka-Rakai region of south-central Uganda. Archived human sera (n = 1,199) retrospectively collected between June 2018 and October 2020 from the population-based Rakai Community Cohort Study were analyzed using both indirect in-house and commercial ID Screen® RVF competition enzyme-linked immunosorbent assays (ELISAs) to detect RVFV IgG antibodies. Household census and socio-demographic data were linked to serological results, and logistic regression was performed to identify factors associated with seropositivity.
RESULTS: RVFV IgG antibodies were detected in 86 of 1,199 (7.8%) individuals. In multivariable analysis, RVFV seropositivity was significantly associated with residence in agrarian communities and older age groups (25-34 and ≥ 35 years), while pig ownership was associated with lower risks of exposure.
CONCLUSION: These findings suggest RVFV human exposure in south-central Uganda and emphasize the need for strengthened surveillance, targeted prevention, and One Health interventions to protect high-risk groups.
METHODS: This cross-sectional study assessed the seroprevalence and associated factors of RVFV exposure among selected communities in the greater Masaka-Rakai region of south-central Uganda. Archived human sera (n = 1,199) retrospectively collected between June 2018 and October 2020 from the population-based Rakai Community Cohort Study were analyzed using both indirect in-house and commercial ID Screen® RVF competition enzyme-linked immunosorbent assays (ELISAs) to detect RVFV IgG antibodies. Household census and socio-demographic data were linked to serological results, and logistic regression was performed to identify factors associated with seropositivity.
RESULTS: RVFV IgG antibodies were detected in 86 of 1,199 (7.8%) individuals. In multivariable analysis, RVFV seropositivity was significantly associated with residence in agrarian communities and older age groups (25-34 and ≥ 35 years), while pig ownership was associated with lower risks of exposure.
CONCLUSION: These findings suggest RVFV human exposure in south-central Uganda and emphasize the need for strengthened surveillance, targeted prevention, and One Health interventions to protect high-risk groups.