Voprosy virusologii · 1975
[Activity and properties of RNA-dependent RNA polymerase induced in cell cultures infected with Venezuelan equine encephalomyelitis virus].
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Pravdina N F, Nikishina V I, Dikiĭ V V, Zhdanov V M
Аннотация
The activity and properties of RNA-dependent RNA-polymerase in cells infected with Venezuelan equine encephalomyelitis virus were studied. The maximum activity of the enzyme was found 4-5 hours after infection. The effect of two synthetic drugs (rimantadine and diacetylaminocyclohexenon) with antiviral activity against some viruses on RNA-polymerase was studied. Rimantadine was shown to have no effect on the synthesis and activity of the enzyme. Diacetylaminocyclohexenon added into the growth medium was found to inhibit production of RNA-polymerase by 35-40% without reducing the activity of the enzyme in vitro.
Предметные рубрики MeSH
AcetatesAdenosine TriphosphateAnimalsAntiviral AgentsBridged-Ring CompoundsChick EmbryoCyclohexylaminesCycloparaffinsCytosine NucleotidesDNA-Directed RNA PolymerasesDactinomycinEncephalitis Virus, Venezuelan EquineEthylaminesFibroblastsGuanine NucleotidesMagnesiumRNA, ViralTritiumUracil NucleotidesUridineVirus Replication