The short term effects of infected gallstones lost intraperitoneally.

In this experimental study, an animal model was set up to evaluate what sort of complications may cause intraperitoneal retained bile stones. Forty rats were divided into 4 groups. The first group was assigned as the control group and the subjects had only laparatomy. In the 2nd group, during laparotomy, sterile bile and bile stones were placed within the peritoneal cavity. In the 3rd group, contaminated bile and bile stones were placed within the peritoneal cavity. In the 4th group, again contaminated bile and bile stones were placed and prophylactic antibiotic (Ceftriaxon) was used for 7 days. After a 4 week interval, survivors were subjected to laparatomy and necropsy. As a conclusion, the peritoneal adhesion difference between the infected bile and stone inooculation group without antibiotic and the other group with antibiotic usage may show that antibiotics might prevent further complications in case of abdominal contamination. Available clinical and experimental data is not enough to recommend laparatomy to collect stones. We conclude that more detailed studies with larger series are necessary to clarify the issue (Tab. 1, Fig. 1, Ref. 26).