Magyar onkologia · 2006
[Results in 42 non-resectable NSCLC IIA-B patients with initial concurrent Taxotere-Cisplatin chemoradiotherapy].
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Szilasi Mária, Horváth Akos, Dolinay Tamás, Szántó János, Brugós László, Lengyel László, Kiss Sándor Sz, Kiss Magdolna, Adamecz Zsolt
Аннотация
GOALS: A prospective multicenter study to treat non-small cell lung cancer (NSCLC) with inductive chemoradiotherapy for improving chances of operability. If used as first-line therapy, combined treatment improves survival and it is well tolerated with a low rate of side effects.
PATIENTS: 42 patients with stage IIIA-B NSCLC from which 36 could be followed.
METHODS: A full dose Taxotere-Cisplatin chemotherapy was given to patients with concurrent radiotherapy in 2 Gy fractions up to 60 Gy via conformal irradiation.
RESULTS: Local response was very high and 40.47% of patients became operable while in inoperable cases consolidation chemotherapy showed similar results as other protocols. We also found a low rate of side effects. The high rate of brain metastasis suggests that prophylactic cranial irradiation (PCI) should be considered.
PATIENTS: 42 patients with stage IIIA-B NSCLC from which 36 could be followed.
METHODS: A full dose Taxotere-Cisplatin chemotherapy was given to patients with concurrent radiotherapy in 2 Gy fractions up to 60 Gy via conformal irradiation.
RESULTS: Local response was very high and 40.47% of patients became operable while in inoperable cases consolidation chemotherapy showed similar results as other protocols. We also found a low rate of side effects. The high rate of brain metastasis suggests that prophylactic cranial irradiation (PCI) should be considered.
Предметные рубрики MeSH
AdultAntineoplastic Combined Chemotherapy ProtocolsBrain NeoplasmsCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCisplatinDocetaxelFemaleHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingProspective StudiesRadiotherapy DosageRadiotherapy, AdjuvantRadiotherapy, ConformalRemission InductionSurvival AnalysisTaxoidsTreatment Outcome