[Prophylactic and therapeutic use of cefotetan, a cephem antibiotic, for infections in the field of obstetrics and gynecology].

This paper deals with results obtained from the cefotetan (CTT, Yamatetan) study group of department of obstetrics and gynecology in Yamagata prefecture. Efficacy of CTT, a new cephamycin antibiotic, was studied in 50 cases (39 cases of prophylactic use for postoperative infections and 11 cases of several different infections). CTT was administered to each of the patients at a daily dose of 2 grams. No other drugs such as antimicrobial agents, steroids and antiinflammatory drugs which might affect the efficacy of CTT were permitted during the study except for the drug therapy or surgical procedures required for treating underlying diseases. Fever index, one of the examination items to assess the prophylactic effect for postoperative infections as well as daily changes in maximum body temperature, was examined in the prophylactic group. Daily changes in febrile pattern were examined in the infection group. The fever index were 3.4 +/- 4.0 degree hours in cases subjected to cesarean sections in the prophylactic group, 3.7 +/- 3.0 degree hours in cases subjected to gynecological operations in the prophylactic group and 4.5 +/- 5.5 degree hours in the infection group. The clinical efficacy rate in the 11 cases of the infection group was 100%; excellent in 3 cases and good in 8 cases. Bacteriological examination was conducted in 3 of the 11 cases and bacteria were eliminated in all 3 cases. The overall clinical efficacy rate was also 100%; excellent in 5 cases and good in 6 cases. No abnormal laboratory findings nor side effects were observed in any of the cases.