Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium.
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Meagher Nicola S, White Kami K, Wilkens Lynne R, Bandera Elisa V, Berchuck Andrew, Carney Michael E, Cramer Daniel W, Cushing-Haugen Kara L, Jordan Susan, Kaufmann Scott H, Le Nhu D, Pike Malcolm C, Riggan Marjorie, Qin Bo, Rothstein Joseph H, Titus Linda, Winham Stacey J, Anton-Culver Hoda, Doherty Jennifer A, Goode Ellen L, Pearce Celeste Leigh, Risch Harvey A, Webb Penelope M, Cook Linda S, Goodman Marc T, Harris Holly R, Le Marchand Loic, McGuire Valerie, Pharoah Paul D P, Sarink Danja, Schildkraut Joellen M, Sieh Weiva, Terry Kathryn L, Thompson Pamela J, Whittemore Alice S, Wu Anna H, Peres Lauren C, Merritt Melissa A
Аннотация
Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n = 785 case and 949 control participants), 266 Native Hawaiian/Pacific Islander (n = 99 case and 167 control participants), 1149 Hispanic (n = 505 case and 644 control participants), and 24 189 White (n = 9981 case and 14 208 control participants) from 11 studies in the Ovarian Cancer Association Consortium. Logistic regression models estimated odds ratios (ORs) and 95% CIs for risk associations by race and ethnicity. Heterogeneity in EOC risk associations by race and ethnicity (P ≤ .02) was observed for oral contraceptive (OC) use, parity, tubal ligation, and smoking. We observed inverse associations with EOC risk for OC use and parity across all groups; associations were strongest in Native Hawaiian/Pacific Islander and Asian women. The inverse association for tubal ligation with risk was most pronounced for Native Hawaiian/Pacific Islander participants (odds ratio (OR) = 0.25; 95% CI, 0.13-0.48) compared with Asian and White participants (OR = 0.68 [95% CI, 0.51-0.90] and OR = 0.78 [95% CI, 0.73-0.85], respectively). Differences in EOC risk factor associations were observed across racial and ethnic groups, which could be due, in part, to varying prevalence of EOC histotypes. Inclusion of greater diversity in future studies is essential to inform prevention strategies. This article is part of a Special Collection on Gynecological Cancers.