Cover Feature: Parameter and state estimation of backers yeast cultivation with a gas sensor array and unscented Kalman filter.

DOI: 10.1002/elsc.202000058 Successful operation, control and optimization of biotechnological process depend on reliable real-time available measurements of the process variables. Although some hardware sensors are readily available, they often have several drawbacks: cost, sample destruction, discrete-time measurements, processing delay, sterilization, disturbances in the hydrodynamic conditions inside the bioreactor, etc. It is therefore of interest to use software sensors [29, 30]. The central idea behind a soft sensor is to use easily accessible on-line data for the estimation of other process variables that are either difficult to measure or only measured at low frequency [30]. The figure illustrates a software sensor for on-line monitoring of substrate and biomass production in backers yeast cultivation. For details see article DOI 10.1002/elsc.202000058 on page 169.