Antimicrobial activity and applications in PMMA of a novel benzpyrole derivant/iodocuprate hybrid (TMBI)2(Cu2I4).

Among individuals who wear removable dentures, there is a significant likelihood, reaching up to 70 %, of experiencing a condition known as denture-induced stomatitis. To address this issue, a commonly used method involves soaking dentures in denture cleansers to eliminate microorganisms. However, the prolonged use of this cleaning method has resulted in the emergence of drug resistance. Composite antibacterial nanomaterials possess excellent chemical, physical, and antibacterial properties, not only allowing the individual components to function but sometimes also leading to synergistic effects that enhance antibacterial performance. In this study, we have successfully synthesized a new benzpyrole derivant/iodocuprate bio-nanomaterial, (TMBI)2(Cu2I4) (TMBI = 1,1,2,3-Tetramethyl-1H-benzo[e]indolium cation), that demonstrates remarkable resistance to Candida albicans, Streptococcus mutans, and dental plaque biofilm.It can effectively clean the surfaces of denture bases by removing Candida albicans, Streptococcus mutans, and dental plaque biofilm. Prolonged immersion in this material does not significantly affect the common mechanical properties of polymethyl methacrylate (PMMA) denture bases. At effective antibacterial concentrations, this nanomaterial (TMBI)2(Cu2I4) demonstrates no residual cytotoxicity on PMMA denture bases after immersion and maintains excellent hemocompatibility. These findings indicate that (TMBI)2(Cu2I4) has the potential to be a promising denture cleanser.