Communications medicine · 2024
Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.
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Posada-Quintero Hugo F, Derrick Bruce J, Ellis M Claire, Natoli Michael J, Winstead-Derlega Christopher, Gonzalez Sara I, Allen Christopher M, Makowski Matthew S, Keuski Brian M, Moon Richard E, Freiberger John J, Chon Ki H
Аннотация
BACKGROUND: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO2) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO2 in the hyperbaric environment (HBO2) as a possible means to predict impending CNS-OT.
METHODS: EDA is recorded during 50 subject exposures (26 subjects) to evaluate CNS-OT in immersed (head out of water) exercising divers in a hyperbaric chamber breathing 100% O2 at 35 feet of seawater (FSW), (PO2 = 2.06 ATA) for up to 120 min.
RESULTS: 32 subject exposures exhibit symptoms "definitely" or "probably" due to CNS-OT before the end of the exposure, whereas 18 do not. We obtain traditional and time-varying spectral indices (TVSymp) of EDA to determine its utility as predictive physio markers. Variations in EDA and heart rate (HR) for the last 5 min of the experiment are compared to baseline values prior to breathing O2. In the subset of experiments where "definite" CNS-OT symptoms developed, we find a significant elevation in the mean ± standard deviation TVSymp value 57 ± 79 s and median of 10 s, prior to symptoms.
CONCLUSIONS: In this retrospective analysis, TVSymp may have predictive value for CNS-OT with high sensitivity (1.0) but lower specificity (0.48). Additional work is being undertaken to improve the detection algorithm.
METHODS: EDA is recorded during 50 subject exposures (26 subjects) to evaluate CNS-OT in immersed (head out of water) exercising divers in a hyperbaric chamber breathing 100% O2 at 35 feet of seawater (FSW), (PO2 = 2.06 ATA) for up to 120 min.
RESULTS: 32 subject exposures exhibit symptoms "definitely" or "probably" due to CNS-OT before the end of the exposure, whereas 18 do not. We obtain traditional and time-varying spectral indices (TVSymp) of EDA to determine its utility as predictive physio markers. Variations in EDA and heart rate (HR) for the last 5 min of the experiment are compared to baseline values prior to breathing O2. In the subset of experiments where "definite" CNS-OT symptoms developed, we find a significant elevation in the mean ± standard deviation TVSymp value 57 ± 79 s and median of 10 s, prior to symptoms.
CONCLUSIONS: In this retrospective analysis, TVSymp may have predictive value for CNS-OT with high sensitivity (1.0) but lower specificity (0.48). Additional work is being undertaken to improve the detection algorithm.