An analytical study of effect of the cell proliferation, half-life, and energy of radionuclides in targeted radiotherapy.

AIM: The treatment of the cancers is one of the most important challenges of nuclear medicine. Using targeted radiotherapy has increased the hope for the cure of the cancers. In the targeted radiotherapy, proliferations of tumor cells during radiotherapy are believed to be main reasons of treatment defeat. The aim of this work is the investigation of the cell proliferation on tumor treatment.

MATERIALS AND

METHODS

For this purpose, two scenarios were considered. The first scenario, in case of the tumor cells nonproliferation, surviving curve of irradiated cells is an exponential function of accumulated dose. The second scenario, Tumor cells proliferate exponentially with a growth constant and all tumor cells are assumed to be proliferating throughout irradiation.

RESULTS

In the nonproliferation condition, the surviving fraction of tumor cells decreases with time. In the proliferation cases, at the beginning of the irradiation, the surviving fraction of cells decreases. If the remained fraction of cells is reduced sufficiently by this time, the tumor may be treated. Unless, as the dose rate continues to decrease, the proliferation exceeds from the sterilization and the tumor cell population increases.

CONCLUSION

Due to high dose-rate, the shorter decay half-life is more effective in comparison to longer ones.