The International journal of biological markers · 2010
Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Moreno-Galván Mónica, Herrera-González Norma Estela, Robles-Pérez Vera, Velasco-Rodríguez Julio C, Tapia-Conyer Roberto, Sarti Elsa
Аннотация
BACKGROUND: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.
OBJECTIVE: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.
MATERIAL AND METHODS: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.
RESULTS: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.
CONCLUSIONS: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
OBJECTIVE: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.
MATERIAL AND METHODS: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.
RESULTS: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.
CONCLUSIONS: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
Предметные рубрики MeSH
AdultAgedBreast NeoplasmsCarcinoma, Ductal, BreastCatechol O-MethyltransferaseContraceptive Agents, FemaleCytochrome P-450 CYP1A1EstrogensFemaleGenetic Predisposition to DiseaseGenotypeHumansMexicoMiddle AgedNeoplasm ProteinsNeoplasms, Hormone-DependentPilot ProjectsPolymorphism, Single NucleotidePostmenopauseReproductive HistoryRiskSmoking