Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.

BACKGROUND

Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.

OBJECTIVE

The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.

MATERIAL AND

METHODS

A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.

RESULTS

The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.

CONCLUSIONS

This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.