Diabetologia · 2006
Is grand multiparity associated with an increased risk of dysglycaemia?
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Simmons D, Shaw J, McKenzie A, Eaton S, Cameron A J, Zimmet P
Аннотация
AIMS/HYPOTHESIS: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity.
SUBJECTS, MATERIALS AND METHODS: Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]).
RESULTS: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status.
CONCLUSIONS/INTERPRETATION: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.
SUBJECTS, MATERIALS AND METHODS: Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]).
RESULTS: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status.
CONCLUSIONS/INTERPRETATION: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAustraliaBlood GlucoseCase-Control StudiesContraceptive Agents, FemaleDiabetes MellitusDiabetes, GestationalFemaleGlucose IntoleranceGlucose Tolerance TestHealth SurveysHumansHysterectomyMiddle AgedParityPostmenopausePregnancyRandom AllocationRisk FactorsSurveys and Questionnaires