BMJ (Clinical research ed.) · 2000
Effect of 1995 pill scare on rates of venous thromboembolism among women taking combined oral contraceptives: analysis of general practice research database.
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Farmer R D, Williams T J, Simpson E L, Nightingale A L
Аннотация
OBJECTIVE: To compare the incidence of venous thromboembolism among women taking combined oral contraceptives before and after the October 1995 pill scare.
DESIGN: Analysis of General Practice Research Database.
SETTING: United Kingdom, January 1993 to December 1998.
SUBJECTS: Women aged 15-49 taking combined oral contraceptives.
MAIN OUTCOME MEASURES: Incidence of venous thromboembolism.
RESULTS: Use of so called "third generation" combined oral contraceptives fell from 53% during January 1993 to October 1995 to 14% during November 1995 to December 1998. There was no significant change in the incidence of venous thromboembolism between the two periods after age was adjusted for (incidence ratio 1.04, 95% confidence interval 0.78 to 1.39).
CONCLUSIONS: The findings are not compatible with the assertion that third generation oral contraceptives are associated with a twofold increase in risk of venous thromboembolism compared with older progestogens.
DESIGN: Analysis of General Practice Research Database.
SETTING: United Kingdom, January 1993 to December 1998.
SUBJECTS: Women aged 15-49 taking combined oral contraceptives.
MAIN OUTCOME MEASURES: Incidence of venous thromboembolism.
RESULTS: Use of so called "third generation" combined oral contraceptives fell from 53% during January 1993 to October 1995 to 14% during November 1995 to December 1998. There was no significant change in the incidence of venous thromboembolism between the two periods after age was adjusted for (incidence ratio 1.04, 95% confidence interval 0.78 to 1.39).
CONCLUSIONS: The findings are not compatible with the assertion that third generation oral contraceptives are associated with a twofold increase in risk of venous thromboembolism compared with older progestogens.